11/24/2023 0 Comments Cla cis 9 trans 11We confirmed that t10, c12-CLA daily gavage performed in mice reduces white adipose tissue (WAT) mass and adiponectin and leptin serum levels and provokes hyperinsulinemia. Here, we investigated the effect of t10, c12-CLA on adipose tissue inflammation, another factor promoting insulin resistance. However, CLA treatment in mice causes insulin resistance that has been attributed to the lipoatrophic state, which is associated with hyperinsulinemia and hepatic steatosis. Many people supplement their diets with CLAs to attempt weight loss, and the trans-10, cis-12 isomer ( t10, c12-CLA) of CLA reduces adiposity in animal models and humans. Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid.
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